JQEZ5
Cat. No.：YN310030
CAS No. ：1913252-04-6
| 产品名称: | JQEZ5 |
| CAS No.: | 1913252-04-6 |
| Chemical Name: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide |
| Synonyms: | JQEZ5;1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide;JQE5;JQEZ-5;GTPL9332;BCP30505;s8607;A16961;N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl |
| 分子量: | 542.68 |
| 分子式: | C₃₀H₃₈N₈O₂ |
| SMILES: | CC(N1N=CC2=C(C(NCC3=C(C=C(NC3=O)C)CCC)=O)C=C(C4=CC=C(N=C4)N5CCN(C)CC5)N=C12)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JQEZ5 是一种有效的选择性的EZH2赖氨酸甲基转移酶抑制剂。JQEZ5 以 SAM 竞争性方式抑制PRC2的酶功能，IC50为 80 nM。JQEZ5 具有抗肿瘤作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bradner, J.E., Qi, J., and Wong, K.K.EZH2 inhibitors and uses thereof,(2016)
Xie, H., Peng, C., Huang, J., et al.Chronic myelogenous leukemia-initiating cells require polycomb group protein EZH2Cancer Discov.6(11),1237-1247(2016)
