3-Deazaneplanocin A
Cat. No.：YN310073
| 产品名称: | 3-Deazaneplanocin A |
| CAS No.: | 102052-95-9 |
| Chemical Name: | 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| Synonyms: | 3-去氮腺嘌呤A; DZNep; 3-Deazaneplanocin |
| 分子量: | 262.26 |
| 分子式: | C₁₂H₁₄N₄O₃ |
| SMILES: | O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Deazaneplanocin A (DZNep) 是一种有效的组蛋白甲基转移酶 (histone methyltransferase，EZH2) 抑制剂。3-Deazaneplanocin A 是一种有效的 S-腺苷同型半胱氨酸水解酶 (AHCY) 抑制剂。 |
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Tseng, C.K.H., Marquez, V.E., Fuller, R.W., et al.Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activitiesJ. Med. Chem.32(7),1442-1446(1989)
Fiskus, W., Wang, Y., Sreekumar, A., et al.Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cellsBlood114(13),2733-2743(2009)
Bissinger, E.M., Heinke, R., Sippl, W., et al.Targeting epigenetic modifiers: Inhibitors of histone methyltransferasesMed. Chem. Commun.1(2),(2010)
