EZM 2302
Cat. No.：YN310108
CAS No. ：1628830-21-6
| 产品名称: | EZM 2302 |
| CAS No.: | 1628830-21-6 |
| Chemical Name: | 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylic acid, methyl ester |
| Synonyms: | GSK3359088 |
| 分子量: | 585.09 |
| 分子式: | C₂₉H₃₇ClN₆O₅ |
| SMILES: | CNC[C@@H](O)COC1=CC=C(Cl)C(C2=NC(N3CC4(CCN(C(OC)=O)CC4)C3)=C(C)C(C5=C(C)ON=C5C)=N2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EZM 2302是共激活因子相关的精氨酸甲基转移酶1 (CARM1) 制剂，IC50值为6 nM。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Drew, A.E., Moradei, O., Jacques, S.L., et al.Identification of a CARM1 inhibitor with potent in vitro and in vivo activity in preclinical models of multiple myelomaSci. Rep.7(1),17993(2017)
Mo, K., Xu, H., Gong, H., et al.Dorsal root ganglia coactivator-associated arginine methyltransferase 1 contributes to peripheral nerve injury-induced pain hypersensitivitiesNeuroscience394,232-242(2018)
