MM-102
Cat. No.：YN310154
| 产品名称: | MM-102 |
| CAS No.: | 1417329-24-8 |
| Chemical Name: | 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide |
| Synonyms: | HMTase Inhibitor IX |
| 分子量: | 669.80 |
| 分子式: | C₃₅H₄₉F₂N₇O₄ |
| SMILES: | O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MM-102 (HMTase Inhibitor IX) 是一种有效的WDR5/MLL相互作用抑制剂, WDR5 结合检测中,IC50=2.4 nM,Ki< 1 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Migliori, V., Mapelli, M., and Guccione, E.On WD40 proteins: Propelling our knowledge of transcriptional control?Epigenetics7(8),815-822(2012)
Guccione, E., Bassi, C., Casadio, F., et al.Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusiveNature449(7164),933-937(2007)
Karatas, H., Townsend, E.C., Cao, F., et al.High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interactionJ. Am. Chem. Soc.135(2),669-682(2013)
