GSK503
Cat. No.：YN310191
CAS No. ：1346572-63-1
| 产品名称: | GSK503 |
| CAS No.: | 1346572-63-1 |
| Chemical Name: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide |
| Synonyms: | GSK-503，GSK 503 |
| 分子量: | 526.67 |
| 分子式: | C₃₁H₃₈N₆O₂ |
| SMILES: | O=C(C1=CC(C2=CC=C(N3CCN(C)CC3)N=C2)=CC4=C1C(C)=CN4C(C)C)NCC5=C(C)C=C(C)NC5=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK503是高效特异性的EZH2甲基转移酶抑制剂，Kiapp值为3到27 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Béguelin, W., Popovic, R., Teater, M., et al.EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformationCancer Cell.23(5),677-692(2013)
Zingg, D., Debbache, J., Schaefer, S.M., et al.The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressorsNat. Commun.6,(2015)
