MS1943
Cat. No.：YN310212
CAS No. ：2225938-17-8
| 产品名称: | MS1943 |
| CAS No.: | 2225938-17-8 |
| Chemical Name: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-[2-[(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl)amino]ethyl]-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide |
| Synonyms: | MS1943 ,MS-1943 ,MS 1943 |
| 分子量: | 718.93 |
| 分子式: | C₄₂H₅₄N₈O₃ |
| SMILES: | CC(C)N(N=C1)C2=C1C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C4=CC=C(N=C4)N(CC5)CCN5CCNC(CC67C[C@H]8C[C@H](C[C@H](C8)C7)C6)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MS1943 是一种首创的，具有口服生物活性的EZH2选择性降解剂，其IC50为 120 nM。MS1943 显著降低了许多三阴性乳腺癌和其他癌及非癌细胞系中的EZH2蛋白水平。MS1943 有效地阻止了多个三阴性乳腺癌和其他癌细胞系的增殖。 |
| IC50和靶点: | [{name:"EZH2:120 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ma, A., Stratikopoulos, E., Park, K.-S., et al.Discovery of a first-in-class EZH2 selective degraderNat. Chem. Biol.16(2),214-222(2020)
