GSK126
Cat. No.：YN310217
CAS No. ：1346574-57-9
| 产品名称: | GSK126 |
| CAS No.: | 1346574-57-9 |
| Chemical Name: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide |
| Synonyms: | GSK2816126A |
| 分子量: | 526.67 |
| 分子式: | C₃₁H₃₈N₆O₂ |
| SMILES: | O=C(C1=CC(C2=CC=C(N3CCNCC3)N=C2)=CC4=C1C(C)=CN4[C@@H](C)CC)NCC5=C(C)C=C(C)NC5=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK126 (GSK2816126A) 是一种有效，选择性的EZH2甲基转移酶抑制剂，IC50为 9.9 nM。 |
| IC50和靶点: | [{name:"EZH2:9.9 nM (IC50)"}] |
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| Solvent & Solubility: |
Simon, J.A., and Lange, C.A.Roles of the EZH2 histone methyltransferase in cancer epigeneticsMutat. Res.647(1-2),21-29(2008)
McCabe, M.T., Ott, H.M., Ganji, G., et al.EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutationsNature492(7427),108-112(2012)
