UNC0646
Cat. No.：YN310247
| 产品名称: | UNC0646 |
| CAS No.: | 1320288-17-2 |
| Chemical Name: | N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine |
| Synonyms: | UNC 0646 |
| 分子量: | 621.90 |
| 分子式: | C₃₆H₅₉N₇O₂ |
| SMILES: | COC1=CC2=C(NC3CCN(C4CCCCC4)CC3)N=C(N5CCN(C(C)C)CCC5)N=C2C=C1OCCCN6CCCCC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UNC0646 是一种有效的选择性组蛋白甲基转移酶G9a抑制剂，其IC50为 6 nM。UNC0646 还是一种有效的GLP抑制剂 (IC50<15 nM)，对G9a/GLP的选择性比 SETD7，SUV39H2，SETD8 和 PRMT3 高。UNC0646 降低 MDA-MB-231 细胞中H3K9me2的水平，IC50为 26 nM。 |
| IC50和靶点: | [{name:"G9a:6 nM (IC50)"},{name: "GLP:<15 nM (IC50)"}] |
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| Solvent & Solubility: |
Liu, F., Barsyte-Lovejoy, D., Allali-Hassani, A., et al.Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolinesJ. Med. Chem.54(17),6139-6150(2011)
Bittencourt, D., Wu, D.Y., Jeong, K.W., et al.G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genesProc. Natl. Acad. Sci. USA109(48),19673-19678(2012)
