Pinometostat
Cat. No.：YN310272
CAS No. ：1380288-87-8
| 产品名称: | Pinometostat |
| CAS No.: | 1380288-87-8 |
| Chemical Name: | 5′-deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-adenosine |
| Synonyms: | EPZ-5676 |
| 分子量: | 562.71 |
| 分子式: | C₃₀H₄₂N₈O₃ |
| SMILES: | NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN([C@@H]4C[C@H](CCC5=NC6=C(C=CC(C(C)(C)C)=C6)N5)C4)C(C)C)O3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pinometostat (EPZ-5676) 是有效的DOT1L组蛋白甲基转移酶抑制剂，Ki为 80 pM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Nguyen, A.T., He, J., Taranova, O., et al.Essential role of DOT1L in maintaining normal adult hematopoiesisCell Res.21(9),1370-1373(2011)
Bernt, K.M., and Armstrong, S.A.A role for DOT1L in MLL-rearranged leukemiasEpigenomics3(6),667-670(2011)
Daigle, S.R., Olhava, E.J., Therkelsen, C.A., et al.Potent inhibition of DOT1L as treatment of MLL-fusion leukemiaBlood122(6),1017-1025(2013)
Basavapathruni, A., Olhava, E.J., Daigle, S.R., et al.Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitorBiopharm. Drug Dispos.35(4),237-252(2014)
