BRD4770
Cat. No.：YN310296
CAS No. ：1374601-40-7
| 产品名称: | BRD4770 |
| CAS No.: | 1374601-40-7 |
| Chemical Name: | 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid, methyl ester |
| Synonyms: | BRD4770;BRD-4770;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester;BRD 4770;GTPL7016;AOB3886;Methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;C25H23N3O3;methyl 2-benzamido-1-(3-phenylpropyl)benzimi |
| 分子量: | 413.47 |
| 分子式: | C₂₅H₂₃N₃O₃ |
| SMILES: | O=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD4770 是一种组蛋白甲基转移酶G9a抑制剂。BRD4770 可抑制H3K9的二甲基和三甲基化，EC50为 5 µM，对 H3K27me3，H3K36me3，H3K4me3 和 H3K79me3 几乎没有影响。BRD4770 可以激活共济失调毛细血管扩张突变 (ATM) 途径并诱导细胞衰老。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yuan, Y., Wang, Q., Paulk, J., et al.A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinomaACS Chem. Biol.7(7),1152-1157(2012)
