EPZ011989
Cat. No.：YN310301
CAS No. ：1598383-40-4
| 产品名称: | EPZ011989 |
| CAS No.: | 1598383-40-4 |
| Chemical Name: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide |
| Synonyms: | EPZ011989 |
| 分子量: | 605.81 |
| 分子式: | C₃₅H₅₁N₅O₄ |
| SMILES: | O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C#CCN3CCOCC3)=CC(N(CC)[C@H]4CC[C@H](N(CCOC)C)CC4)=C2C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EPZ011989是EZH2高效选择性且口服型抑制剂，对wt EZH2以及EZH2突变型Ki值<3nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Simon, J.A., and Lange, C.A.Roles of the EZH2 histone methyltransferase in cancer epigeneticsMutat. Res.647(1-2),21-29(2008)
Campbell, J.E., Kuntz, K.W., Knutson, S.K., et al.EPZ011989, a potent, orally-available EZH2 inhibitor with robust in vivo activityACS Med. Chem. Lett.6(5),491-495(2015)
