PFI-2 hydrochloride
Cat. No.：YN310304
| 产品名称: | PFI-2 hydrochloride |
| CAS No.: | 1627607-87-7 |
| Chemical Name: | 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride |
| Synonyms: | PFI-2, PFI2,PFI 2,R PFI-2,R-PFI2 |
| 分子量: | 535.98 |
| 分子式: | C₂₃H₂₆ClF₄N₃O₃S |
| SMILES: | O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PFI-2盐酸盐是甲基转移酶SETD7高效选择性抑制剂，IC50值为2nM。 |
| IC50和靶点: | |
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Couture, J.F., Collazo, E., Hauk, G., et al.Structural basis for the methylation site specificity of SET7/9Nat. Struct. Mol. Biol.13(2),140-146(2006)
Kurash, J.K., Lei, H., Shen, Q., et al.Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivoMol. Cell29,392-400(2008)
Barsyte-Lovejoy, D., Li, F., Oudhoff, M.J., et al.(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cellsProc. Natl. Acad. Sci. USA111(35),12853-12858(2014)
