WDR5-0103
Cat. No.：YN310320
CAS No. ：890190-22-4
| 产品名称: | WDR5-0103 |
| CAS No.: | 890190-22-4 |
| Chemical Name: | 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-benzoic acid, methyl ester |
| Synonyms: | WD-Repeat Protein 5-0103 |
| 分子量: | 383.44 |
| 分子式: | C₂₁H₂₅N₃O₄ |
| SMILES: | O=C(OC)C1=CC=C(N2CCN(C)CC2)C(NC(C3=CC=CC(OC)=C3)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WDR5-0103是一个有效的含WD重复序列蛋白5 (WDR5) 选择性拮抗剂, Kd值为450 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Migliori, V., Mapelli, M., and Guccione, E.On WD40 proteins: Propelling our knowledge of transcriptional control?Epigenetics7(8),815-822(2012)
Guccione, E., Bassi, C., Casadio, F., et al.Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusiveNature449(7164),933-937(2007)
Guelman, S., Kozuka, K., Mao, Y., et al.The double-histone-acetyltransferase complex ATAC is essential for mammalian developmentMol. Cell. Biol.29(5),1176-1188(2009)
Senisterra, G., Wu, H., Allali-Hassani, A., et al.Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5Biochem. J.449(1),151-159(2013)
Wigle, T.J., and Copeland, R.A.Drugging the human methylome: An emerging modality for reversible control of aberrant gene transcriptionCurr. Opin. Chem. Biol.17(3),369-378(2013)
