MS023
Cat. No.：YN310325
CAS No. ：1831110-54-3
| 产品名称: | MS023 |
| CAS No.: | 1831110-54-3 |
| Chemical Name: | N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine |
| Synonyms: | MS-023，MS 023 |
| 分子量: | 287.40 |
| 分子式: | C₁₇H₂₅N₃O |
| SMILES: | CN(CCN)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MS023 是一种有效选择性的，具有细胞活性的人I 型蛋白精氨酸甲基转移酶 (PRMTs)抑制剂，对PRMT1，PRMT3，PRMT4，PRMT6和PRMT8的IC50分别为 30，119，83，4 和 5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Eram, M.S., Shen, Y., Szewczyk, M.M., et al.A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferasesACS Chem. Biol.11(3),772-781(2015)
Cai, T., Yu, Z., Wang, Z., et al.Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replicationJ. Biol. Chem.297(1),100821(2021)
Hu, G., Yan, C., Xie, P., et al.PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylationExp. Cell Res.394(2),112152(2020)
