XY1
Cat. No.：YN310327
CAS No. ：1624117-53-8
| 产品名称: | XY1 |
| CAS No.: | 1624117-53-8 |
| Chemical Name: | N-2-naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea |
| Synonyms: | N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲 |
| 分子量: | 297.35 |
| 分子式: | C₁₇H₁₉N₃O₂ |
| SMILES: | O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=CC=CC3=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XY1是SGC707的一种类似物 (SGC707是一种有效的, 选择性PRMT3抑制剂, IC50值为31 nM), 但XY1对PRMT3完全无活性的。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Tang, J., Gary, J.D., Clarke, S., et al.PRMT3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulationJ. Biol. Chem.273(27),16935-16945(1998)
Wolf, S.S.The protein arginine methyltransferase family: An update about function, new perspectives and the physiological role in humansCell. Mol. Life Sci.66(13),2109-2121(2009)
Kaniskan, H.Ü., Szewczyk, M.M., Yu, Z., et al.A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)Angew. Chem. Int. Ed. Engl.54(17),5166-5170(2015)
