IOX1
Cat. No.：YN310162
| 产品名称: | IOX1 |
| CAS No.: | 5852-78-8 |
| Chemical Name: | 8-hydroxy-5-quinolinecarboxylic acid |
| Synonyms: | 5-羰基-8-羟基喹啉 |
| 分子量: | 189.17 |
| 分子式: | C₁₀H₇NO₃ |
| SMILES: | O=C(C1=C2C=CC=NC2=C(O)C=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IOX1，是 2OG 氧合酶 (2OGoxygenases) 的有效广谱抑制剂，包括 JmjC 去甲基酶。IOX1 抑制 KDM4C，KDM4E，KDM2A，KDM3A 和 KDM6B 的IC50值分别为 0.6 μM，2.3 μM，1.8 μM，0.1 μM 和 1.4 μM。IOX1 抑制 ALKBH5。 |
| IC50和靶点: | |
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Kawamura, A., Tumber, A., Rose, N.R., et al.Development of homogeneous luminescence assays for histone demethylase catalysis and bindingAnal. Biochem.404,86-93(2010)
Hewitson, K.S., Holmes, S.L., Ehrismann, D., et al.Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH)J. Biol. Chem.283(38),25971-25978(2008)
Rose, N.R., Ng, S.S., Mecinovic, J., et al.Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylasesJ. Med. Chem.51(22),7053-7056(2008)
King, O.N.F., Li, X.S., Sakurai, M., et al.Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitorsPLoS One5(11),1-12(2010)
Flashman, E., Bagg, A.L., Chowdhury, R., et al.Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylasesJ. Biol. Chem.283(7),3808-3815(2008)
