ASTX660
Cat. No.：YN270090
CAS No. ：1799328-86-1
| 产品名称: | ASTX660 |
| CAS No.: | 1799328-86-1 |
| Chemical Name: | 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-ethanone |
| Synonyms: | ASTX 660;ASTX-660 |
| 分子量: | 539.68 |
| 分子式: | C₃₀H₄₂FN₅O₃ |
| SMILES: | C[C@H]1N(C[C@@H]2N(CC(N3CC(C)(C)C4=NC(CO)=C(CC5=CC=C(F)C=C5)C=C43)=O)C[C@@H](C)NC2)CCOC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ASTX660 是细胞凋亡蛋白抑制剂 (cIAP) 和 X 连锁凋亡抑制蛋白 (XIAP) 的口服生物可用的双重拮抗剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ward, G.A., Lewis, E.J., Ahn, J.S., et al.ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNFα-dependent apoptosis in cancer cell lines and inhibits tumor growthMol. Cancer Ther.17(7),1381-1391(2018)
