GDC-0152
Cat. No.：YN270252
CAS No. ：873652-48-3
| 产品名称: | GDC-0152 |
| CAS No.: | 873652-48-3 |
| Chemical Name: | N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-L-prolinamide |
| Synonyms: | GDC0152 |
| 分子量: | 498.64 |
| 分子式: | C₂₅H₃₄N₆O₃S |
| SMILES: | O=C(N1[C@H](C(NC2=C(C3=CC=CC=C3)N=NS2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GDC-0152 是一种有效的IAPs抑制剂，可以与XIAP，cIAP1和cIAP2的 BIR3 结合域，以及ML-IAP的 BIR 结合域结合，Ki值分别为 28 nM，17 nM，43 nM 和 14 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Goyal, L.Cell death inhibition:Keeping caspases in checkCell104,805-808(2001)
Flygare, J.A., Beresini, M., Budha, N., et al.Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)J. Med. Chem.55(9),4101-4113(2012)
Hu, R., Li, J., Liu, Z., et al.GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K/Akt signaling pathwayTumour Biol.36(2),577-584(2015)
Erickson, R.I., Tarrant, J., Cain, G., et al.Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacologyToxicol. Sci.131(1),247-258(2013)
