AG1024
Cat. No.：YN440069
CAS No. ：65678-07-1
规格
价格(RMB)
库存
| 产品名称: | AG1024 |
| CAS No.: | 65678-07-1 |
| Chemical Name: | 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-propanedinitrile |
| Synonyms: | Tyrphostin AG 1024 |
| 分子量: | 305.17 |
| 分子式: | C₁₄H₁₃BrN₂O |
| SMILES: | N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG1024 (Tyrphostin AG 1024) 是一种可逆的，竞争性和选择性的胰岛素样生长因子-1 受体 (IGF-1R) 抑制剂，IC50为 7 μM。AG1024 抑制胰岛素受体 (IR) 的磷酸化 (IC50=57 μM)。AG1024 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Párrizas, M., Gazit, A., Levitzki, A., et al.Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostinsEndocrinology138(4),1427-1433(1997)
Wen, B., Deutsch, E., Marangoni, E., et al.Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cellsBr. J. Cancer85(12),2017-2021(2001)
Kisielewska, J., Ligeza, J., and Klein, A.The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth prostate cancer cells (DU145)Folia Histochem. Cytobiol.46(2),185-191(2008)
