PQ401
Cat. No.：YN440288
CAS No. ：196868-63-0
规格
价格(RMB)
库存
| 产品名称: | PQ401 |
| CAS No.: | 196868-63-0 |
| Chemical Name: | N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea |
| Synonyms: | IGF-1R Inhibitor II |
| 分子量: | 341.79 |
| 分子式: | C₁₈H₁₆ClN₃O₂ |
| SMILES: | O=C(NC1=CC(C)=NC2=CC=CC=C12)NC3=C(OC)C=CC(Cl)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PQ401 是一种有效的IGF-IR抑制剂。在 MCF-7 细胞中，PQ401 抑制 IGF-I 刺激的 IGF-IR 自磷酸化，IC50为 12.0 μM。PQ401 可有效抑制 IGF-I 刺激的 MCF-7 细胞生长 (IC50为 6 μM)。PQ401 有潜力用于乳腺癌和其他对 IGF-I 敏感的癌症的研究。PQ401 诱导 caspase 介导的细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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Gable, K.L., Maddux, B.A., Penaranda, C., et al.Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growthMol. Cancer Ther.5(4),1079-1086(2006)
Zhou, X., Zhao, X., Li, X., et al.PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cellsJ. Chemother.28(1),44-49(2016)
Zhang, Y., Anderson, M., Weisman, J.L., et al.Evaluation of diarylureas for activity against Plasmodium falciparumACS Med. Chem. Lett.1(9),460-465(2010)
