Picropodophyllin
Cat. No.：YN440328
CAS No. ：477-47-4
规格
价格(RMB)
库存
| 产品名称: | Picropodophyllin |
| CAS No.: | 477-47-4 |
| Chemical Name: | (5R,5aS,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
| Synonyms: | 苦鬼臼毒素; AXL1717; |
| 分子量: | 414.41 |
| 分子式: | C₂₂H₂₂O₈ |
| SMILES: | O=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@@]21[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Picropodophyllin (AXL1717) 是选择性的胰岛素样生长因子-1受体 (IGF-1R)抑制剂，IC50为1 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Girnita, A., Girnita, L., del Prete, F., et al.Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growthCancer Res.64(1),236-242(2004)
Strömberg, T., Ekman, S., Girnita, L., et al.IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cellsBlood107(2),669-678(2006)
Economou, M.A., Wu, J., Vasilcanu, D., et al.Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptorInvest. Opthalmol. Vis. Sci.49(6),2620-2626(2008)
