SU9516
Cat. No.：YN270370
| 产品名称: | SU9516 |
| CAS No.: | 377090-84-1 |
| Chemical Name: | 1,3-dihydro-3Z-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one |
| Synonyms: | SU 9516，SU-9516 |
| 分子量: | 241.25 |
| 分子式: | C₁₃H₁₁N₃O₂ |
| SMILES: | O=C1NC2=C(C=C(OC)C=C2)/C1=C/C3=CN=CN3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SU9516 是一种有效的CDK2抑制剂，IC50值为 22 nM，同时对 CDK1 和 CDK4 也有抑制作用，IC50值分别为 40 和 200 nM。 |
| IC50和靶点: | [{name:"CDK2:22 nM (IC50)"},{name: "CDK1:40 nM (IC50)"},{name: "CDK4:200 nM (IC50)"},{name: "PDGFr:18000 nM (IC50)"}] |
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Lane, M.E., Yu, B., Rice, A., et al.A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cellsCancer Res.61(16),6170-6177(2001)
Yu, B., Lane, M.E., and Wadler, S.SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cellsBiochem. Pharmacol.64(7),1091-1100(2002)
Gao, N., Kramer, L., Rahmani, M., et al.The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanismMol. Pharmacol.70(2),645-655(2006)
