Agmatine sulfate
Cat. No.：YN320116
| 产品名称: | Agmatine sulfate |
| CAS No.: | 2482-00-0 |
| Chemical Name: | N-(4-aminobutyl)-guanidine, monosulfate |
| Synonyms: | Agmatine sulfate salt,硫酸胍基丁胺 |
| 分子量: | 228.27 |
| 分子式: | C₅H₁₆N₄O₄S |
| SMILES: | NC(NCCCCN)=N.O=S(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Agmatine sulfate在多个靶点上发挥调节作用，如神经递质系统，离子通道，一氧化氮合成。它是imidazoline receptor的内源性激动剂和NO synthase抑制剂。 |
| IC50和靶点: | |
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Reis, D.J., and Regunathan, S.Is agmatine a novel neurotransmitter in brain?Trends Pharmacol. Sci.21(5),187-193(2000)
Piletz, J.E.Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and α-2 adrenergic receptorsJ. Pharmacol. Exp. Ther.272(2),581-587(1995)
Yang, X.C., and Reis, D.J.Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neuronsJ. Pharmacol. Exp. Ther.288(2),544-549(1999)
Loring, R.H.Agmatine acts as an antagonist of neuronal nicotinic receptorsBr. J. Pharmacol.99(1),207-211(1990)
Molderings, G.J., Schmidt, K., Bönisch, H., et al.Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of σ2 binding sitesNaunyn Schmiedebergs Arch. Pharmacol.345(3),245-252(1996)
Shepherd, R.M., Hashmi, M.N., Kane, C., et al.Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin releaseBr. J. Pharmacol.119(5),911-916(1996)
Demady, D.R., Jianmongkol, S., Vuletich, J.L., et al.Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzymeMol. Pharmacol.59(1),24-29(2001)
Kolesnikov, Y., Jain, S., and Pasternak, G.W.Modulation of opioid analgesia by agmatineEur. J. Pharmacol.296(1),17-22(1996)
Schwartz, D., Peterson, O.W., Mendonca, M., et al.Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanismAm. J. Physiol.272(5 Pt 2),F597-F601(1997)
