Emricasan
Cat. No.：YN250099
| 产品名称: | Emricasan |
| CAS No.: | 254750-02-2 |
| Chemical Name: | N-[2-(1,1-dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide |
| Synonyms: | 恩利卡生; PF 03491390; IDN-6556 |
| 分子量: | 569.50 |
| 分子式: | C₂₆H₂₇F₄N₃O₇ |
| SMILES: | FC1=C(C(F)=C(C=C1F)F)OCC([C@@H](NC([C@@H](NC(C(NC2=C(C=CC=C2)C(C)(C)C)=O)=O)C)=O)CC(O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Emricasan (PF 03491390) 是一种口服有效的 不可逆pan-caspase抑制剂。Emricasan 抑制 Zika 病毒 (ZIKV) 诱导的caspase-3活性增加并保护了人类皮层神经祖细胞。 |
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Natori, S., Higuchi, H., Contreras, P., et al.The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injuryLiver Transpl.9(3),278-284(2003)
Hoglen, N.C., Chen, L.S., Fisher, C.D., et al.Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): A liver-targeted caspase inhibitorJ. Pharmacol. Exp. Ther.309(2),634-640(2004)
Barreyro, F.J., Holod, S., Finocchietto, P.V., et al.The pan-caspase inhibitor emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitisLiver Int.35(3),953-966(2015)
McCall, M.D., Maciver, A.M., Kin, T., et al.Caspase inhibitor IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant modelTransplantation94(1),30-35(2012)
