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Iniparib

Cat. No.:YN250297

  • CAS No. :160003-66-7

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    • 生物活性
    • 参考文献
    • 产品名称: Iniparib
      CAS No.: 160003-66-7
      Chemical Name: 4-iodo-3-nitro-benzamide
      Synonyms:BSI-201; NSC-746045; IND-71677
      分子量:292.03
      分子式:C₇H₅IN₂O₃
      SMILES:O=C(C1=CC=C(C([N+]([O-])=O)=C1)I)N
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Iniparib (BSI-201) 是一种不可逆的PARP1抑制剂,可用于三阴性乳腺癌的研究。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Yuan, Y., Liao, Y.M., Hsueh, C.T., et al.Novel targeted therapeutics: Inhibitors of MDM2, ALK and PARPJ. Hematol. Oncol.4(16),1-14(2011)

      Javle, M., and Curtin, N.J.The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapyTher. Adv. Med. Oncol.3(6),257-267(2011)

      Plummer, R.Poly(ADP-ribose) polymerase inhibition: A new direction for BRCA and triple-negative breast cancer?Breast Cancer Res.13(4),1-6(2011)

      Bauer, P.I., Mendeleyeva, J., Kirsten, E., et al.Anti-cancer action of 4-iodo-3-nitrobenzamide in combination with buthionine sulfoximine: Inactivation of poly(ADP-ribose) polymerase and tumor glycolysis and the appearance of a poly(ADP-ribose) polymerase proteaseBiochem. Pharmacol.63,455-462(2002)

      Mendeleyev, J., Kirsten, E., Hakam, A., et al.Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamideBiochem. Pharmacol.50(5),705-714(1995)

      O'Shaughnessy, J., Osborne, C., Pippen, J.E., et al.Iniparib plus chemotherapy in metastatic triple-negative breast cancerN. Engl. J. Med.364(3),205-214(2011)

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    稀释计算器 :
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