Hesperadin
Cat. No.：YN250301
CAS No. ：422513-13-1
| 产品名称: | Hesperadin |
| CAS No.: | 422513-13-1 |
| Chemical Name: | N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide |
| Synonyms: | 橙皮甙，橙皮苷 |
| 分子量: | 516.65 |
| 分子式: | C₂₉H₃₂N₄O₃S |
| SMILES: | O=C1NC2=CC=C(C=C2/C1=C(NC3=CC=C(C=C3)CN4CCCCC4)\C5=CC=CC=C5)NS(CC)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hesperadin 是Aurora A和B的 ATP 竞争性吲哚酮抑制剂。Hesperadin 以 250 nM 的IC50抑制 Aurora B。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hauf, S., Cole, R.W., LaTerra, S., et al.The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpointJ. Cell. Biol.161(2),281-294(2003)
Jetton, N., Rothberg, K.G., Hubbard, J.G., et al.The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream formsMol. Microbiol.72(2),442-458(2009)
Girdler, F., Gascoigne, K.E., Eyers, P.A., et al.Validating Aurora B as an anti-cancer drug targetJ. Cell Sci.119(Pt 17),3664-3675(2006)
Patel, G., Roncal, N.E., Lee, P.J., et al.Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discoveryMedchemcomm.5(5),655-658(2014)
Hu, Y., Zhang, J., Musharrafieh, R., et al.Chemical genomics approach leads to the identification of hesperadin, an Aurora B kinase inhibitor, as a broad-spectrum influenza antiviralInt. J. Mol. Sci.18(9),pii: E1929(2017)
