Pimodivir
Cat. No.：YN250337
CAS No. ：1629869-44-8
| 产品名称: | Pimodivir |
| CAS No.: | 1629869-44-8 |
| Chemical Name: | (2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-bicyclo[2.2.2]octane-2-carboxylic acid |
| Synonyms: | VX-787 |
| 分子量: | 399.39 |
| 分子式: | C₂₀H₁₉F₂N₅O₂ |
| SMILES: | O=C([C@H]1C(CC2)CCC2[C@@H]1NC3=NC(C4=CNC5=NC=C(F)C=C54)=NC=C3F)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pimodivir (VX-787) 是一种可口服的甲型流感病毒聚合酶抑制剂，通过抑制PB2亚基起作用。 |
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Clark, M.P., Ledeboer, M.W., Davies, I., et al.Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2J. Med. Chem.57(15),6668-6678(2014)
Byrn, R.A., Jones, S.M., Bennett, H.B., et al.Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunitAntimicrob. Agents Chemother.59(3),1569-1582(2014)
