Umifenovir hydrochloride
Cat. No.:YN250612
CAS No. :131707-23-8
产品名称: | Umifenovir hydrochloride |
CAS No.: | 131707-23-8 |
Chemical Name: | 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid, ethyl ester, monohydrochloride |
Synonyms: | 盐酸阿比多尔 |
分子量: | 513.88 |
分子式: | C₂₂H₂₆BrClN₂O₃S |
SMILES: | O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC.[H]Cl |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Umifenovir hydrochloride 是一种有效的口服广谱抗病毒药物,对多种包膜和非包膜病毒均有活性。Umifenovir hydrochloride 被用作抗流感病毒 (anti-influenza virus) 剂。Umifenovir hydrochloride 能有效抑制病毒与宿主细胞的融合。Umifenovir hydrochloride 是一种有效的SARS-CoV-2体外抑制剂。具有抗炎活性。 |
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Boriskin, Y.S., Leneva, I.A., Pécheur, E.I., et al.Arbidol: A broad-spectrum antiviral compound that blocks viral fusionCurr. Med. Chem.15(10),997-1005(2008)
Pizzorno, A., Padey, B., Dubois, J., et al.In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2Antiviral Res.181,104878(2020)
Fink, S.L., Vojtech, L., Wagoner, J., et al.The antiviral drug arbidol inhibits Zika virusSci. Rep.8(1),8989(2018)
Wang, Y., Ding, Y., Yang, C., et al.Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret)Biomed. Pharmacother.91,393-401(2017)