UNC0638
Cat. No.：YN250627
| 产品名称: | UNC0638 |
| CAS No.: | 1255580-76-7 |
| Chemical Name: | 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine |
| Synonyms: | UNC 0638; UNC0638 |
| 分子量: | 509.73 |
| 分子式: | C₃₀H₄₇N₅O₂ |
| SMILES: | CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(C5CCCCC5)=N2)CC1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UNC0638 选择性抑制G9a和GLP组蛋白甲基转移酶，IC50分别为15 nM 和 19 nM。UNC0638 具有抗FMDV(口蹄疫病毒) 和抗VSV(水疱性口炎病毒) 的活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tachibana, M., Sugimoto, K., Nozaki, M., et al.G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisGenes Dev.16(14),1779-1791(2002)
Wagschal, A., Sutherland, H.G., Woodfine, K., et al.G9a histone methyltransferase contributes to imprinting in the mouse placentaMol. Cell Biol.28(3),1104-1113(2008)
Thomas, L.R., Miyashita, H., Cobb, R.M., et al.Functional analysis of histone methyltransferase G9a in B and T lymphocytesJ. Immunol.181(1),485-493(2008)
G9a/GLP selective methyltransferase chemical probe, UNC0638,(2010)
