Scriptaid
Cat. No.：YN250641
| 产品名称: | Scriptaid |
| CAS No.: | 287383-59-9 |
| Chemical Name: | N-hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexananmide |
| Synonyms: | Scriptide; GCK1026 |
| 分子量: | 326.35 |
| 分子式: | C₁₈H₁₈N₂O₄ |
| SMILES: | O=C(NO)CCCCCN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Scriptaid 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂，可用于癌症研究。Scriptaid 也是一种抗病毒药的敏化剂，可用于与爱泼斯坦-巴尔病毒 (EBV) 相关的淋巴瘤的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Su, G.H., Sohn, T.A., Ryu, B., et al.A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound libraryCancer Res.60(12),3137-3142(2000)
Keen, J.C., Yan, L., Mack, K.M., et al.A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor α (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidineBreast Cancer Res. Treat.81(3),177-186(2003)
Lee, E.J., Lee, B.B., Kim, S.J., et al.Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cellsInt. J. Oncol.33(4),767-776(2008)
Van Thuan, N., Bui, H.T., Kim, J.H., et al.The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred miceReproduction138(2),309-317(2009)
