Peramivir
Cat. No.：YN250693
| 产品名称: | Peramivir |
| CAS No.: | 330600-85-6 |
| Chemical Name: | (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid |
| Synonyms: | 帕拉米韦; RWJ-270201; BCX-1812 |
| 分子量: | 328.41 |
| 分子式: | C₁₅H₂₈N₄O₄ |
| SMILES: | O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Peramivir (RWJ-270201;BCX-1812) 是一种高效、选择性和口服有效的流感病毒神经氨酸酶(NA)抑制剂，对 9 个亚型 NA 抑制作用的IC50值为 0.9-4.3 nM。 |
| IC50和靶点: | |
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Young, D., Fowler, C., and Bush, K.RWJ-270201 (BCX-1812): A novel neuraminidase inhibitor for influenzaPhilos. Trans. R. Soc. Lond. B Biol. Sci356(1416),1905-1913(2001)
Yun, N.E., Linde, N.S., Zacks, M.A., et al.Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)Virology374(1),198-209(2008)
