Oseltamivir phosphate
Cat. No.：YN250694
| 产品名称: | Oseltamivir phosphate |
| CAS No.: | 204255-11-8 |
| Chemical Name: | 4R-(acetylamino)-5S-amino-3R-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid, ethyl ester, monophosphate |
| Synonyms: | 磷酸奥司他韦; GS 4104 |
| 分子量: | 410.40 |
| 分子式: | C₁₆H₃₁N₂O₈P |
| SMILES: | O=C(OCC)C1=C[C@H]([C@@H]([C@H](C1)N)NC(C)=O)OC(CC)CC.OP(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oseltamivir phosphate (GS 4104) 是一种神经氨酸酶 (neuraminidase) 抑制剂，用于流感 (influenza A和B) 的研究。 |
| IC50和靶点: | |
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Sidwell, R.W., Huffman, J.H., Barnard, D.L., et al.Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitorAntiviral Res.37(2),107-120(1998)
Hayden, F.G., Atmar, R.L., Schilling, M., et al.Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenzaN. Engl. J. Med.341(18),1336-1343(1999)
Li, W., Escarpe, P.S., Eisenberg, E.J., et al.Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071Antimicrob. Agents Chemother.42(3),647-653(1998)
Oliyai, R., Yuan, L.C., Dahl, T.C., et al.Biexponential decomposition of a neuraminidase inhibitor prodrug (GS-4104) in aqueous solutionPharm. Res.15(8),1300-1304(1998)
Govorkova, E.A., Ilyushina, N.A., McClaren, J.L., et al.Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse modelAntimicrob. Agents Chemother.53(7),3088-3096(2009)
Krueger, A.C., Xu, Y., Kati, W.M., et al.Synthesis of potent pyrrolidine influenza neuraminidase inhibitorsBioorg. Med. Chem. Lett.18(5),1692-1695(2008)
Lew, W., Wu, H., Chen, X., et al.Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: Synthesis and inhibitory activityBioorg. Med. Chem. Lett.10(11),1257-1260(2000)
