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Amantadine hydrochloride

Cat. No.:YN251032

  • CAS No. :665-66-7

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    • 生物活性
    • 参考文献
    • 产品名称: Amantadine hydrochloride
      CAS No.: 665-66-7
      Chemical Name: tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride
      Synonyms:盐酸金刚烷胺; 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride
      分子量:187.71
      分子式:C₁₀H₁₈ClN
      SMILES:NC1(C2)C[C@@H]3C[C@@H](C[C@H]2C3)C1.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Amantadine (1-Adamantanamine) hydrochloride 是一种抗甲型流感 (influenza A) 病毒的抗病毒药物。Amantadine hydrochloride 阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。Amantadine hydrochloride 抗帕金森病剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Bresink, I., Benke, T.A., Collett, V.J., et al.Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cellsBr. J. Pharmacol.119(2),195-204(1996)

      Rey-Carrizo, M., Torres, E., Ma, C., et al.3-Azatetracyclo[5.2.1.15,8.01,5]undecane derivatives: From wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutantJ. Med. Chem.56(22),9265-9274(2013)

      Smee, D.F., Julander, J.G., Tarbet, E.B., et al.Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agentsAntiviral Res.96(1),13-20(2012)

      Bido, S., Marti, M., and Morari, M.Amantadine attenuates levodopa-induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levelsJ. Neurochem.118(6),1043-1055(2011)

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