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Harringtonine

Cat. No.:YN251543

  • CAS No. :26833-85-2

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Harringtonine
      CAS No.: 26833-85-2
      Chemical Name: 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine
      Synonyms:FH15975
      分子量:531.59
      分子式:C₂₈H₃₇NO₉
      SMILES:O=C([C@@](CC(OC)=O)(O)CCC(C)(O)C)O[C@H]1[C@](C2=CC(OCO3)=C3C=C2CCN4CCC5)([H])[C@]45C=C1OC
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Harringtonine是一种天然的Cephalotaxus生物碱,可抑制蛋白质合成。Harringtonine 具有抗基孔肯雅 (CHIKV) 病毒的活性,EC50为 0.24 μM。
      IC50和靶点:
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      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Fresno, M., Jiménez, A., and Vázquez, D.Inhibition of translation in eukaryotic systems by harringtonineEur. J. Biochem.72(2),323-330(1977)

      Ingolia, N.T., Brar, G.A., Rouskin, S., et al.The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragmentsNat. Protoc.7(8),1534-1550(2012)

      Kantarjian, H.M., O'Brien, S., Anderlini, P., et al.Treatment of chronic myelogenous leukemia: Current status and investigational optionsBlood87(8),3069-3081(1996)

      Chen, Y., Peng, C., Sullivan, C., et al.Novel therapeutic agents against cancer stem cells of chronic myeloid leukemiaAnticancer Agents Med. Chem.10(2),111-115(2010)

      Robert, F., Carrier, M., Rawe, S., et al.Altering chemosensitivity by modulating translation elongationPLoS One4(5),e5428(2009)

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