Cephaeline
Cat. No.：YN251648
CAS No. ：483-17-0
规格
价格(RMB)
库存
| 产品名称: | Cephaeline |
| CAS No.: | 483-17-0 |
| Chemical Name: | (1R)-1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol |
| Synonyms: | 吐根酚碱 |
| 分子量: | 466.61 |
| 分子式: | C₂₈H₃₈N₂O₄ |
| SMILES: | OC1=CC2=C([C@@H](C[C@@H]3[C@@H](CC)CN4CCC5=CC(OC)=C(OC)C=C5[C@]4([H])C3)NCC2)C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cephaeline 是 Indian Ipecac 中的酚类生物碱。Cephaeline 对病毒 ZIKV 和 EBOV 感染均有高效的抑制作用。 |
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Asano, T., Kushida, H., Sadakane, C., et al.Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activitiesBiol. Pharm. Bull.24(6),678-682(2001)
Yang, S., Xu, M., Lee, E.M., et al.Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entryCell. Discov.4,31(2018)
Hasegawa, M., Sasaki, T., Sadakane, K., et al.Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: Involvement of 5-hydroxytryptamine receptorsJpn. J. Pharmacol.89(2),113-119(2002)
Boyd, E.M., and Knight, L.M.The expectorant action of cephaeline, emetine and 2-dehydroemetineJ. Pharm. Pharmacol.16,118-124(1964)
