L-826266
Cat. No.：YN322424
| 产品名称: | L-826266 |
| CAS No.: | 244101-03-9 |
| Chemical Name: | (2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[5-chloro-2-(2-naphthalenylmethyl)phenyl]-2-propenamide |
| Synonyms: | L-826,266 |
| 分子量: | 570.9 |
| 分子式: | C27H21BrClNO4S |
| SMILES: | ClC(C=C1/C=C/C(NS(C2=C(OC)C=CC(Br)=C2)(=O)=O)=O)=CC=C1CC3=CC4=CC=CC=C4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-826266 是一种选择性和竞争性的EP3受体拮抗剂，可用于惊厥性疾病的研究。 |
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Juteau, H., Gareau, Y., Labelle, M., et al.Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptorBioorg. Med. Chem.9(8),1977-1984(2001)
Kozłowska, H., Baranowska-Kuczko, M., Schlicker, E., et al.EP3 receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed ratsPharmacol. Rep.64(6),1526-1536(2012)
Günther, J., Schulte, K., Wenzel, D., et al.Prostaglandins of the E series inhibit monoamine release via EP3 receptors: Proof with the competitive EP3 receptor antagonist L-826,266Naunyn Schmiedebergs Arch. Pharmacol.381(1),21-31(2010)
