E7820
Cat. No.：YN300036
CAS No. ：289483-69-8
| 产品名称: | E7820 |
| CAS No.: | 289483-69-8 |
| Chemical Name: | 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-benzenesulfonamide |
| Synonyms: | ER68203-00 |
| 分子量: | 336.37 |
| 分子式: | C₁₇H₁₂N₄O₂S |
| SMILES: | O=S(C1=CC(C#N)=CC=C1)(NC2=C(NC=C3C#N)C3=C(C)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | E7820 (ER68203-00) 是一种具有口服活性芳香族磺酰胺衍生物，是一种独特的血管生成 (angiogenesis) 抑制剂，可抑制内皮上整合素 α2 (integrin alpha2) 亚基的表达。E7820 抑制大鼠主动脉血管生成，IC50为 0.11 μg/ml。E7820 调节 α-1，α-2，α-3 和 α-5 整联素 mRNA 表达。具有抗血管生成和抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Funahashi, Y., Sugi, N.H., Semba, T., et al.Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endotheliumCancer Res.62(21),6116-6123(2002)
Semba, T., Funahashi, Y., Ono, N., et al.An angiogenesis inhibitor E7820 shows broad-spectrum tumor growth inhibition in a xenograft model: Possible value of integrin α2 on platelets as a biological markerClin. Cancer Res.10(4),1430-1438(2004)
