Lifitegrast
Cat. No.：YN300053
CAS No. ：1025967-78-5
| 产品名称: | Lifitegrast |
| CAS No.: | 1025967-78-5 |
| Chemical Name: | N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine |
| Synonyms: | 立他司特; SAR 1118; SHP-606 |
| 分子量: | 615.48 |
| 分子式: | C₂₉H₂₄Cl₂N₂O₇S |
| SMILES: | O=C(O)[C@H](CC1=CC=CC(S(=O)(C)=O)=C1)NC(C2=C(Cl)C3=C(CN(C(C4=CC=C5C=COC5=C4)=O)CC3)C=C2Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lifitegrast (SAR 1118) 是整合素淋巴细胞功能相关抗原-1(LFA-1)的拮抗剂; 抑制Jurkat T细胞附着于ICAM-1的IC50为2.98nM。 |
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Zhong, M., Gadek, T.R., Bui, M., et al.Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eyeACS Med. Chem. Lett.3(3),203-206(2012)
Semba, C.P., and Gadek, T.R.Development of lifitegrast: A novel T-cell inhibitor for the treatment of dry eye diseaseClin. Ophthalmol.10,1083-1094(2016)
Murphy, C.J., Bentley, E., Miller, P.E., et al.The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogsInvest. Opthalmol. Vis. Sci.52(6),3174-3180(2011)
Sun, Y., Zhang, R., Gadek, T.R., et al.Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)J. Ocul. Pharmacol. Ther.29(4),395-402(2013)
