Irigenin
Cat. No.：YN300062
| 产品名称: | Irigenin |
| CAS No.: | 548-76-5 |
| Chemical Name: | 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one |
| Synonyms: | 4H-1-Benzopyran-4-one,5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-;5,7-Dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4-benzopyrone;5,7-dihydroxy-3-(3-hyd |
| 分子量: | 360.31 |
| 分子式: | C₁₈H₁₆O₈ |
| SMILES: | O=C1C(C2=CC(OC)=C(OC)C(O)=C2)=COC3=CC(O)=C(OC)C(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Irigenin 是一种先导化合物，通过特异性和选择性地阻断 Extra Domain A (EDA) 域的 C-C 环上α9β1和α4β1整合素结合位点，介导其抗转移作用。Irigenin 具有抗癌作用。它通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡。 |
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Raju, K.S.R., Kadian, N., Taneja, I., et al.Phytochemical analysis of isoflavonoids using liquid chromatography coupled with tandem mass spectrometryPhytochem. Rev.14(3),469–498(2015)
Wollenweber, E., Stevens, J.F., Klimo, K., et al.Cancer chemopreventive in vitro activities of isoflavones isolated from Iris germanicaPlanta Med.69(1),15-20(2003)
Ahn, K.S., Noh, E.J., Cha, K.-H., et al.Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E2 production in murine macrophage RAW 264.7 cellsLife Sci.78(20),2336-2342(2006)
Guo, L., Zheng, X., Wang, E., et al.Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425Biomed. Pharmacother.125,109784(2020)
