AZD-1480
Cat. No.：YN340029
CAS No. ：935666-88-9
| 产品名称: | AZD-1480 |
| CAS No.: | 935666-88-9 |
| Chemical Name: | 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
| Synonyms: | AZD 1480,AZD-1480 |
| 分子量: | 348.77 |
| 分子式: | C₁₄H₁₄ClFN₈ |
| SMILES: | ClC1=C(N=C(N=C1)N[C@@H](C)C2=NC=C(C=N2)F)NC3=NNC(C)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD-1480 是一种 ATP 竞争型的JAK1和JAK2抑制剂，IC50分别为 1.3 nM 和 0.4 nM。 |
| IC50和靶点: | [{name:"JAK2:<0.4 nM (IC50)"},{name: "JAK1:1.3 nM (IC50)"}] |
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Gozgit, J.M., Bebernitz, G., Patil, P., et al.Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2J. Biol. Chem.283(47),32334-32343(2008)
Hedvat, M., Huszar, D., Herrmann, A., et al.The JAK2 inhibitor AZD1480 potently blocks stat3 signaling and oncogenesis in solid tumorsCancer Cell16(6),487-497(2009)
Ioannidis, S., Lamb, M.L., Wang, T., et al.Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathwayJ. Med. Chem.54(1),262-276(2010)
Scuto, A., Krejci, P., Popplewell, L., et al.The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survivalLeukemia25(3),538-550(2011)
Xin, H., Herrmann, A., Reckamp, K., et al.Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480Cancer Res.71(21),6601-6610(2011)
