Gusacitinib
Cat. No.：YN340037
CAS No. ：1425381-60-7
| 产品名称: | Gusacitinib |
| CAS No.: | 1425381-60-7 |
| Chemical Name: | 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile |
| Synonyms: | ASN-002 |
| 分子量: | 460.53 |
| 分子式: | C₂₄H₂₈N₈O₂ |
| SMILES: | N#CCC1CCN(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C5C(C=NNC5=O)=N2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gusacitinib (ASN-002) 是一种有效的SYK激酶和JAK激酶的双抑制剂，IC50值为 5-46 nM。Gusacitinib 在实体和血液肿瘤中均具有抗癌活性。 |
| IC50和靶点: | |
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Bissonnette, R., Maari, C., Forman, S., et al.The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: Results from a randomized double-blind placebo-controlled studyBr. J. Dermatol.181(4),733-742(2019)
