TG101209
Cat. No.：YN340056
CAS No. ：936091-14-4
| 产品名称: | TG101209 |
| CAS No.: | 936091-14-4 |
| Chemical Name: | N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-benzenesulfonamide |
| Synonyms: | TG 101209; TG-101209 |
| 分子量: | 509.67 |
| 分子式: | C₂₆H₃₅N₇O₂S |
| SMILES: | O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2C)=C1)(NC(C)(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TG101209 是一种选择性的，有效的JAK2抑制剂，IC50值为 6 nM；同时能抑制Flt3，和RET的活性，IC50值分别为 25 nM 和 17 nM。 |
| IC50和靶点: | [{name:"JAK2:6 nM (IC50)"},{name: "JAK3:169 nM (IC50)"},{name: "RET:17 nM (IC50)"},{name: "FLT3:25 nM (IC50)"}] |
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| Solvent & Solubility: |
Pardanani, A., Lasho, T., Levine, R.L., et al.TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutationsLeukemia21(8),1658-1668(2007)
Ramakrishnan, V., Kimlinger, T., Haug, J., et al.TG101209, a novel JAK2 inhibitor, has significant in-vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cellsAm. J. Hematol.85(9),675-686(2010)
