AZ960
Cat. No.：YN340057
CAS No. ：905586-69-8
| 产品名称: | AZ960 |
| CAS No.: | 905586-69-8 |
| Chemical Name: | 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile |
| Synonyms: | AZ 960 |
| 分子量: | 354.36 |
| 分子式: | C₁₈H₁₆F₂N₆ |
| SMILES: | N#CC1=CC(F)=C(NC2=NNC(C)=C2)N=C1N[C@H](C3=CC=C(F)C=C3)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ960是高效选择性的JAK2激酶抑制剂，Ki值为0.45 nM。 |
| IC50和靶点: | [{name:"JAK2:0.45 nM (Ki)"},{name: "JAK2:<3 nM (IC50)"},{name: "JAK3:9 nM (IC50)"}] |
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| Solvent & Solubility: |
Gozgit, J.M., Bebernitz, G., Patil, P., et al.Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2J. Biol. Chem.283(47),32334-32343(2008)
Yang, J., Ikezoe, T., Nishioka, C., et al.AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cellsMol. Cancer Ther.9(12),3386-3395(2010)
