AZD4205
Cat. No.：YN340060
CAS No. ：2091134-68-6
| 产品名称: | AZD4205 |
| CAS No.: | 2091134-68-6 |
| Chemical Name: | (αR)-N-[3-[2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-1H-indol-7-yl]-α,4-dimethyl-1-piperazineacetamide |
| Synonyms: | AZD4205 |
| 分子量: | 489.57 |
| 分子式: | C₂₅H₃₁N₉O₂ |
| SMILES: | C[C@@H](N1CCN(C)CC1)C(NC2=C3C(C(C4=NC(NC5=CN(C)N=C5OC)=NC=C4)=CN3)=CC=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD4205 是一种选择性的JAK1抑制剂，IC50值为 73 nM，对 JAK2 的抑制作用较弱 (IC50>14.7 μM)，对 JAK3 的抑制作用很小 (IC50>30 μM)。 |
| IC50和靶点: | [{name:"JAK1:73 nM (IC50)"}] |
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| Solvent & Solubility: |
Su, Q., Banks, E., Bebernitz, G., et al.Discovery of (2R)- N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a potent and selective Janus kinase 1 inhibitorJ. Med. Chem.63(9),4517-4527(2020)
