Delgocitinib
Cat. No.：YN340065
| 产品名称: | Delgocitinib |
| CAS No.: | 1263774-59-9 |
| Chemical Name: | (3S,4R)-3-methyl-β-oxo-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-propanenitrile |
| Synonyms: | JTE-052 |
| 分子量: | 310.35 |
| 分子式: | C₁₆H₁₈N₆O |
| SMILES: | O=C(N(C[C@@H]1C)[C@]21CN(C3=C(C=CN4)C4=NC=N3)CC2)CC#N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Delgocitinib (JTE-052) 是一种特异性的JAK抑制剂，对 JAK1, JAK2, JAK3 和 Tyk2 的IC50值分别为 2.8，2.6，13 和 58 nM。 |
| IC50和靶点: | [{name:"JAK1:2.8 nM (IC50)"},{name: "JAK2:2.6 nM (IC50)"},{name: "JAK3:13 nM (IC50)"},{name: "Tyk2:58 nM (IC50)"}] |
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Noji, S., Hara, Y., Miura, T., et al.Discovery of a Janus kinase inhibitor bearing a highly three-dimensional spiro scaffold: JTE-052 (delgocitinib) as a new dermatological agent to treat inflammatory skin disordersJ. Med. Chem.63(13),7163-7185(2020)
Yamamoto, Y., Otsuka, A., Nakashima, C., et al.Janus kinase inhibitor delgocitinib suppresses pruritus and nerve elongation in an atopic dermatitis murine modelJ. Dermatol. Sci.97(2),161-164(2020)
