PF-06700841 P-Tosylate
Cat. No.：YN340079
CAS No. ：2140301-96-6
| 产品名称: | PF-06700841 P-Tosylate |
| CAS No.: | 2140301-96-6 |
| Chemical Name: | [(1S)-2,2-difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone, 4-methylbenzenesulfonate |
| Synonyms: | PF-06700841 P-Tosylate |
| 分子量: | 561.60 |
| 分子式: | C₂₅H₂₉F₂N₇O₄S |
| SMILES: | O=C([C@H]1C(F)(F)C1)N2C3CN(C4=NC(NC5=CN(C)N=C5)=NC=C4)CC2CC3.O=S(C6=CC=C(C)C=C6)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-06700841 P-Tosylate 是一种有效的JAK1和TYK2双重抑制剂，IC50值分别为 17 nM 和 23 nM。PF-06700841 P-Tosylate 还分别以IC50值为 77 nM 和 6.49 μM 抑制JAK2和JAK3。 |
| IC50和靶点: | [{name:"JAK1:17 nM (IC50)"},{name: "JAK2:77 nM (IC50)"},{name: "JAK3:6.9 μM (IC50)"}] |
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| Solvent & Solubility: |
Fensome, A., Ambler, C.M., Arnold, E., et al.Dual inhibition of TYK2 and JAK1 for the treatment of autoimmune diseases: Discovery of ((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)J. Med. Chem.,(2018)
