SHR0302
Cat. No.：YN340080
| 产品名称: | SHR0302 |
| CAS No.: | 1445987-21-2 |
| Chemical Name: | |
| Synonyms: | ARQ252 |
| 分子量: | 414.48 |
| 分子式: | C₁₈H₂₂N₈O₂S |
| SMILES: | O=C(N1C[C@@]2([H])[C@@](C[C@H](N(C)C3=C4C(NC=C4)=NC=N3)C2)([H])C1)NC5=NC(OC)=NS5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SHR0302 是一种有效的具有口服活性的JAK抑制剂，尤其是JAK1的抑制剂。SHR0302 对JAK1的选择性是JAK2的 10 倍以上，是JAK3的 77 倍，是Tyk2的 420 倍。SHR0302 抑制JAK1-STAT3磷酸化并诱导肝星状细胞凋亡 (apoptosis)。SHR0302 具有抗增殖和抗炎作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
