Decernotinib
Cat. No.：YN340101
CAS No. ：944842-54-0
| 产品名称: | Decernotinib |
| CAS No.: | 944842-54-0 |
| Chemical Name: | (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-N-(2,2,2-trifluoroethyl)-butanamide |
| Synonyms: | VX-509; VRT-831509 |
| 分子量: | 392.38 |
| 分子式: | C₁₈H₁₉F₃N₆O |
| SMILES: | C[C@](C(NCC(F)(F)F)=O)(CC)NC1=NC(C2=CNC3=NC=CC=C32)=NC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Decernotinib 是一种有效的，可口服的JAK3抑制剂，对JAK3，JAK1，JAK2 和 TYK2 的Ki值分别为 2.5，11，13 和 11 nM。 |
| IC50和靶点: | [{name:"JAK3:2.5 nM (Ki)"},{name: "JAK1:11 nM (Ki)"},{name: "Tyk2:11 nM (Ki)"},{name: "JAK2:13 nM (Ki)"},{name: "FLT3:1 μM (Ki)"},{name: "ROCK I:1.5 μM (Ki)"},{name: "GSK3β:1.8 μM (Ki)"},{name: "CDK2/CycA:2.6 μM (Ki)"},{name: "PknB:8 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mahajan, S., Hogan, J.K., Shlyakhter, D., et al.VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune diseaseJ. Pharmacol. Exp. Ther.353(2),405-414(2016)
