ZM39923 hydrochloride
Cat. No.：YN340104
| 产品名称: | ZM39923 hydrochloride |
| CAS No.: | 1021868-92-7 |
| Chemical Name: | 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone, monohydrochloride |
| Synonyms: | ZM 39923 HCl,JAK3 Inhibitor IV |
| 分子量: | 367.91 |
| 分子式: | C₂₃H₂₆ClNO |
| SMILES: | O=C(C1=CC=C2C=CC=CC2=C1)CCN(C(C)C)CC3=CC=CC=C3.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZM39923 hydrochloride 是一种JAK3抑制剂，pIC50值为 7.1；ZM39923 hydrochloride 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50值为 10 nM。 |
| IC50和靶点: | [{name:"JAK3:7.1 (pIC50)"},{name: "JAK1:4.4 (pIC50)"},{name: "EGF-R:5.6 (pIC50)"},{name: "Lck:5.0 (pIC50)"},{name: "CDK4:5.0 (pIC50)"},{name: "TGM2:10 nM (IC50)"}] |
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Brown, G.R., Bamford, A.M., Bowyer, J., et al.Naphthyl ketones: A new class of Janus kinase 3 inhibitorsBioorg. Med. Chem. Lett.10(6),575-579(2000)
Lai, T.-S., Liu, Y., Tucker, T., et al.Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug librariesChem. Biol.15(9),969-978(2008)
