Gandotinib
Cat. No.：YN340120
CAS No. ：1229236-86-5
| 产品名称: | Gandotinib |
| CAS No.: | 1229236-86-5 |
| Chemical Name: | 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)-imidazo[1,2-b]pyridazin-6-amine |
| Synonyms: | LY2784544 |
| 分子量: | 469.94 |
| 分子式: | C₂₃H₂₅ClFN₇O |
| SMILES: | CC1=NNC(NC2=NN3C(C(CN4CCOCC4)=C2)=NC(C)=C3CC5=CC=C(C=C5F)Cl)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gandotinib (LY2784544) 是一种有效的JAK2抑制剂，IC50为 3 nM。Gandotinib (LY2784544) 也抑制FLT3，FLT4，FGFR2，TYK2 和 TRKB，IC50分别为 4，25，32，44 和 95 nM。 |
| IC50和靶点: | [{name:"JAK2:3 nM (IC50)"},{name: "FGFR2:32 nM (IC50)"},{name: "Flt-4:25 nM (IC50)"},{name: "Tyk2:44 nM (IC50)"},{name: "JAK3:48 nM (IC50)"},{name: "FGFR3:106 nM (IC50)"},{name: "KDR:109 nM (IC50)"},{name: "FLT3:4 nM (IC50)"},{name: "TRKB:95 nM (IC50)"},{name: "ALK:138 nM (IC50)"},{name: "MUSK:147 nM (IC50)"},{name: "AURKA:168 nM (IC50)"},{name: "MAP3K9:299 nM (IC50)"}] |
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| Solvent & Solubility: |
Ma, L., Clayton, J.R., Walgren, R.A., et al.Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617FBlood Cancer J.3(4),e109(2013)
Furqan, M., Mukhi, N., Lee, B., et al.Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical applicationBiomark. Res.1(1),5(2013)
